The window of opportunity: A relevant concept for axial spondyloarthritis

Robinson, Philip C. and Brown, Matthew A. (2014) The window of opportunity: A relevant concept for axial spondyloarthritis. Arthritis Research and Therapy, 16 3: . doi:10.1186/ar4561

Author Robinson, Philip C.
Brown, Matthew A.
Title The window of opportunity: A relevant concept for axial spondyloarthritis
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1478-6362
Publication date 2014-05-12
Year available 2014
Sub-type Article (original research)
DOI 10.1186/ar4561
Open Access Status DOI
Volume 16
Issue 3
Total pages 3
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Language eng
Abstract The window of opportunity is a concept critical to rheumatoid arthritis treatment. Early treatment changes the outcome of rheumatoid arthritis treatment, in that response rates are higher with earlier disease-modifying anti-rheumatic drug treatment and damage is substantially reduced. Axial spondyloarthritis is an inflammatory axial disease encompassing both nonradiographic axial spondyloarthritis and established ankylosing spondylitis. In axial spondyloarthritis, studies of magnetic resonance imaging as well as tumor necrosis factor inhibitor treatment and withdrawal studies all suggest that early effective suppression of inflammation has the potential to reduce radiographic damage. This potential would suggest that the concept of a window of opportunity is relevant not only to rheumatoid arthritis but also to axial spondyloarthritis. The challenge now remains to identify high-risk patients early and to commence treatment without delay. Developments in risk stratification include new classification criteria, identification of clinical risk factors, biomarkers, genetic associations, potential antibody associations and an ankylosing spondylitis-specific microbiome signature. Further research needs to focus on the evidence for early intervention and the early identification of high-risk individuals.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
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