L-carnitine for the treatment of acute myocardial infarction

DiNicolantonio, James J., Niazi, Asfandyar K., McCarty, Mark F., Lavie, Carl J., Liberopoulos, Evangelos and O'Keefe, James H. (2014) L-carnitine for the treatment of acute myocardial infarction. Reviews in Cardiovascular Medicine, 15 1: 52-62. doi:10.3909/ricm0710

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Author DiNicolantonio, James J.
Niazi, Asfandyar K.
McCarty, Mark F.
Lavie, Carl J.
Liberopoulos, Evangelos
O'Keefe, James H.
Title L-carnitine for the treatment of acute myocardial infarction
Journal name Reviews in Cardiovascular Medicine   Check publisher's open access policy
ISSN 1530-6550
Publication date 2014-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3909/ricm0710
Open Access Status
Volume 15
Issue 1
Start page 52
End page 62
Total pages 11
Place of publication New York, United States
Publisher MedReviews
Collection year 2015
Language eng
Formatted abstract
Although the therapeutic strategies available for treating acute myocardial infarction (AMI) have evolved dramatically in recent decades, coronary artery disease remains the leading cause of death in our society, and the rates of recurrent myocardial infarction and mortality are still unacceptably high. Therefore, exploration of alternative therapeutic strategies for AMI is of utmost importance. One such strategy is to target metabolic pathways via L-carnitine supplementation. L-carnitine is a physiologically essential metabolic cofactor that has been shown to provide a plethora of benefits when administered after AMI. L-carnitine has been shown to lessen infarct size, to reduce ventricular arrhythmias, left ventricular dilation, and heart failure incidence, as well as improve survival. These benefits may, in part, be related to its ability to boost glucose oxidation in ischemic tissues, while moderating increases in fatty acyl-coenzyme A levels that can impair mitochondrial efficiency and promote oxidative stress and inflammation. This article summarizes the evidence pertinent to the therapeutic use of L-carnitine for AMI.
Keyword Acute myocardial infarction
Fatty acids
Adenine Nucleotide Translocator
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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