Strain background determines lymphoma incidence in Atm knockout mice

Genik, Paula C., Bielefeldt-Ohmann, Helle, Liu, Xianan, Story, Michael D., Ding, Lianghao, Bush, Jamie M., Fallgren, Christina M. and Weil, Michael M. (2014) Strain background determines lymphoma incidence in Atm knockout mice. Neoplasia, 16 2: 129-136. doi:10.1593/neo.131980

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Author Genik, Paula C.
Bielefeldt-Ohmann, Helle
Liu, Xianan
Story, Michael D.
Ding, Lianghao
Bush, Jamie M.
Fallgren, Christina M.
Weil, Michael M.
Title Strain background determines lymphoma incidence in Atm knockout mice
Formatted title
Strain background determines lymphoma incidence in Atm knockout mice
Journal name Neoplasia   Check publisher's open access policy
ISSN 1476-5586
1522-8002
Publication date 2014-02
Year available 2014
Sub-type Article (original research)
DOI 10.1593/neo.131980
Open Access Status DOI
Volume 16
Issue 2
Start page 129
End page 136
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
About 10% to 30% of patients with ataxia-telangiectasia (A-T) develop leukemias or lymphomas. There is considerable interpatient variation in the age of onset and leukemia/lymphoma type. The incomplete penetrance and variable age of onset may be attributable to several factors. These include competing mortality from other A-T-associated pathologies, particularly neurodegeneration and interstitial lung disease, allele-specific effects of ataxia-telangiectasia mutated (ATM) gene mutations. There is also limited evidence from clinical observations and studies using Atm knockout mice that modifier genes may account for some variation in leukemia/lymphoma susceptibility. We have introgressed the Atmtm1Awb knockout allele (Atm) onto several inbred murine strains and observed differences in thymic lymphoma incidence and latency between Atm-/- mice on the different strain backgrounds and between their F1 hybrids. The lymphomas that arose in these mice had a pattern of sequence gains and losses that were similar to those previously described by others. These results provide further evidence for the existence of modifier genes controlling lymphomagenesis in individuals carrying defective copies of Atm, at least in mice, the characterized Atm congenic strain set provides a resource with which to identify these genes. In addition, we found that fewer than expected Atm-/- pups were weaned on two strain backgrounds and that there was no correlation between body weight of young Atm-/- mice and lymphoma incidence or latency.
Keyword ATM protein
Lymphoma
Leukemia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Veterinary Science Publications
 
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