Acellular pertussis vaccine effectiveness for children during the 2009-2010 pertussis epidemic in QueenslandAcellular pertussis vaccine effectiveness for children

Sheridan, Sarah L., McCall, Bradley J., Davis, Craig A., Robson, Jennifer M. B., Hull, Brynley P., Selvey, Christine E., Ware, Robert S., Grimwood, Keith and Lambert, Stephen B. (2014) Acellular pertussis vaccine effectiveness for children during the 2009-2010 pertussis epidemic in QueenslandAcellular pertussis vaccine effectiveness for children. Medical Journal of Australia, 200 6: 334-338. doi:10.5694/mja13.11069


Author Sheridan, Sarah L.
McCall, Bradley J.
Davis, Craig A.
Robson, Jennifer M. B.
Hull, Brynley P.
Selvey, Christine E.
Ware, Robert S.
Grimwood, Keith
Lambert, Stephen B.
Title Acellular pertussis vaccine effectiveness for children during the 2009-2010 pertussis epidemic in QueenslandAcellular pertussis vaccine effectiveness for children
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
1326-5377
Publication date 2014-04
Year available 2014
Sub-type Article (original research)
DOI 10.5694/mja13.11069
Volume 200
Issue 6
Start page 334
End page 338
Total pages 5
Place of publication Strawberry Hills, NSW Australia
Publisher Australasian Medical Publishing Company
Collection year 2015
Language eng
Formatted abstract
Objectives: To assess the effectiveness of three, four and five doses of acellular pertussis vaccine against pertussis notification for children aged 1 – < 4 years and 5 – < 12 years, and the effectiveness of three doses of acellular pertussis vaccine against pertussis hospitalisation for children aged 1 – < 4 years.

Design, setting and participants: A population-based retrospective study of children aged 1 – < 12 years residing in Queensland, Australia, during 2009 and 2010. Routinely collected notification, hospitalisation, testing and vaccination data were used to describe notification rates and testing patterns and to assess vaccine effectiveness (VE) by the screening method.

Main outcome measures: VE against pertussis notification for children aged 1 – < 4 years and 5 – < 12 years, by birth year, and VE against pertussis hospitalisation for children aged 1 – < 4 years.

Results: 1961 notifications and 29 hospitalisations were included in the VE calculations. VE point estimates against pertussis notification and hospitalisation in children aged 1 – < 4 years were similar in 2009 and 2010, and ranged between 83.5% and 89.4%. VE point estimates against notification among children aged 5 – < 12 years were between 71.2% and 87.7% in 2009, and between 34.7% and 70.3% in 2010. The numbers of pertussis tests performed for children, particularly polymerase chain reaction (PCR) tests, increased between 2009 and 2010.

Conclusions: Acellular pertussis vaccine provided good protection within the first years of priming, but this waned as age increased. Changes in pertussis testing behaviour, because of increases in PCR use and awareness, may have contributed to increased pertussis notification rates and lower estimates of VE against notification owing to
Keyword Childhood Immunization Register
Whole Cell
Australia
Protection
California
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Children's Medical Research Institute Publications
School of Public Health Publications
 
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