Improving the osteogenic behaviour of human mesenchymal stromal cells

Ivkovic, A., Porter, R. M., Wells, J. W. and Evans, C. H. (2008). Improving the osteogenic behaviour of human mesenchymal stromal cells. In: eCM IX Musculoskeletal Trauma: 50 Years of AO Research. Abstracts. ECM IX: Musculoskeletal Trauma - 50 Years of AO Research, Davos, Switzerland, (21-21). 15-18 June, 2008.


Author Ivkovic, A.
Porter, R. M.
Wells, J. W.
Evans, C. H.
Title of paper Improving the osteogenic behaviour of human mesenchymal stromal cells
Conference name ECM IX: Musculoskeletal Trauma - 50 Years of AO Research
Conference location Davos, Switzerland
Conference dates 15-18 June, 2008
Proceedings title eCM IX Musculoskeletal Trauma: 50 Years of AO Research. Abstracts   Check publisher's open access policy
Journal name European Cells and Materials   Check publisher's open access policy
Place of Publication Clavadelstr, Davos, Switzerland
Publisher Swiss Society for Biomaterials
Publication Year 2008
Year available 2008
Sub-type Published abstract
Open Access Status Link (no DOI)
ISSN 1473-2262
Volume 16
Issue Suppl. 2
Start page 21
End page 21
Total pages 1
Language eng
Formatted Abstract/Summary
Bone marrow contains mesenchymal stromal cells (MSCs), which can undergo osteoblastic differentiation when cultured under the appropriate conditions. The utilization of MSCs to generate osteoblasts presents an attractive opportunity for addressing orthopaedic problems that require substantial bone formation. To achieve this goal, it is first necessary to develop protocols that optimize MSC osteogenesis. Recombinant BMP-2 and BMP-7 are in clinical use for bone healing, but MSCs of human origin are only moderately responsive to these proteins, and deposit limited amounts of mineral in vitro in response to them (1). Recent reports indicate that other BMPs may be more important for hMSC osteogenesis (2). Another promising strategy is pre-treatment of these cells with histone deacetylase inhibitors (HDIs) (3). Here, we investigated the effects of BMP-6, BMP-9and HDIs on the osteogenic behavior of hMSCs in monolayer culture...
Subjects 1303 Specialist Studies in Education
1307 Cell Biology
1502 Banking, Finance and Investment
2204 Religion and Religious Studies
2502 Biomaterials
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Other title: "Improving the osteogenic behavior of human mesenchymal stromal cells".

Document type: Conference Paper
Collection: UQ Diamantina Institute Publications
 
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Created: Fri, 23 May 2014, 12:36:14 EST by Dr James Wells on behalf of UQ Diamantina Institute