Inflammasomes and inflammation

Chen, Kaiwen W., Richards, Ayanthi A., Zamoshnikova, Alina and Schroder, Kate (2014). Inflammasomes and inflammation. In Yusuke Hiraku, Shosuke Kawanishi and Hiroshi Ohshima (Ed.), Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects (pp. 103-117) Hoboken, NJ, USA: John Wiley & Sons. doi:10.1002/9781118826621.ch8

Author Chen, Kaiwen W.
Richards, Ayanthi A.
Zamoshnikova, Alina
Schroder, Kate
Title of chapter Inflammasomes and inflammation
Title of book Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects
Place of Publication Hoboken, NJ, USA
Publisher John Wiley & Sons
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1002/9781118826621.ch8
Open Access Status
ISBN 9781118160305
Editor Yusuke Hiraku
Shosuke Kawanishi
Hiroshi Ohshima
Chapter number 8
Start page 103
End page 117
Total pages 15
Total chapters 23
Collection year 2015
Language eng
Formatted Abstract/Summary
Engagement of pattern recognition receptors (PRRs) initiates signal transduction pathways that usually culminate in the elimination of pathogens and/or the initiation of tissue repair processes. A major pro-inflammatory pathway mediating host defense against infection is triggered by inflammasomes, multiprotein complexes that regulate the function of the pro-inflammatory caspase, caspase-1. Caspase-1, in turn, controls the maturation and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18 and the induction of inflammatory cell death (pyroptosis). Inflammasome assembly is mediated by members of the NOD-like receptor (NLR) or pyrin and HIN domain–containing (PYHIN) families of “danger” sensor proteins. This chapter focuses on certain types of inflammasomes namely, NLRP3 inflammasome, IPAF inflammasome, NLRP1 inflammasome, NLRP12 inflammasome, NLRP7 inflammasome, NLRP6 inflammasome, and AIM2 inflammasome. Numerous and diverse human disorders of wide-ranging etiology arise from, or are exacerbated by, the dysregulation of inflammasome activity. They include genetic disorders, autoimmune conditions, and metabolic diseases.
Keyword Autoinflammatory diseases
Cytokine targets
NOD-like receptors
Pattern recognition receptors (PRRs)
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 22 May 2014, 11:58:30 EST by Susan Allen on behalf of Institute for Molecular Bioscience