MRI signal phase oscillates with neuronal activity in cerebral cortex: implications for neuronal current imaging

Du, Jiaxin, Vegh, Viktor and Reutens, David C. (2014) MRI signal phase oscillates with neuronal activity in cerebral cortex: implications for neuronal current imaging. NeuroImage, 94 1-11. doi:10.1016/j.neuroimage.2014.03.015

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Author Du, Jiaxin
Vegh, Viktor
Reutens, David C.
Title MRI signal phase oscillates with neuronal activity in cerebral cortex: implications for neuronal current imaging
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2014-07-01
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2014.03.015
Open Access Status File (Author Post-print)
Volume 94
Start page 1
End page 11
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract Neuronal activity produces transient ionic currents that may be detectable using magnetic resonance imaging (MRI). We examined the feasibility of MRI-based detection of neuronal currents using computer simulations based on the laminar cortex model (LCM). Instead of simulating the activity of single neurons, we decomposed neuronal activity to action potentials (AP) and postsynaptic potentials (PSP). The geometries of dendrites and axons were generated dynamically to account for diverse neuronal morphologies. Magnetic fields associated with APs and PSPs were calculated during spontaneous and stimulated cortical activity, from which the neuronal current induced MRI signal was determined. We found that the MRI signal magnitude change (< 0.1 ppm) is below currently detectable levels but that the signal phase change is likely to be detectable. Furthermore, neuronal MRI signals are sensitive to temporal and spatial variations in neuronal activity but independent of the intensity of neuronal activation. Synchronised neuronal activity produces large phase changes (in the order of 0.1 mrad). However, signal phase oscillates with neuronal activity. Consequently, MRI scans need to be synchronised with neuronal oscillations to maximise the likelihood of detecting signal phase changes due to neuronal currents. These findings inform the design of MRI experiments to detect neuronal currents.
Keyword Magnetic resonance imaging
Neuronal current imaging
Neuronal magnetic field
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
 
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Created: Thu, 22 May 2014, 11:32:52 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging