Modified human contrast sensitivity function based phase mask for susceptibility-weighted imaging

Wang, Wei-Hsin, Reutens, David C., Yang, Zhengyi, Nguyen, Giang and Vegh, Viktor (2014) Modified human contrast sensitivity function based phase mask for susceptibility-weighted imaging. NeuroImage: Clinical, 4 765-778. doi:10.1016/j.nicl.2014.04.012


Author Wang, Wei-Hsin
Reutens, David C.
Yang, Zhengyi
Nguyen, Giang
Vegh, Viktor
Title Modified human contrast sensitivity function based phase mask for susceptibility-weighted imaging
Journal name NeuroImage: Clinical   Check publisher's open access policy
ISSN 2213-1582
Publication date 2014
Sub-type Article (original research)
DOI 10.1016/j.nicl.2014.04.012
Open Access Status DOI
Volume 4
Start page 765
End page 778
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Highlights
•Perception of image content is defined by the human contrast sensitivity function.
•Human contrast sensitivity function enhanced susceptibility weighted images.
•Marked increase in spatial frequency perception of brain images was achieved.
•The approach can potentially be used to improve diagnosis of diseases and disorders.

The aim of the work is to increase the visual information in magnetic resonance imaging based susceptibility weighted images. Our approach is to amplify spatial frequency information of the phase mask used to increase susceptibility weighting using a modified version of the human contrast sensitivity function. Thereby, we propose a modified version of the human contrast sensitivity function for use in phase mask creation. Comparison with conventional susceptibility-weighted imaging was undertaken on a qualitative basis and quantitatively with a number of established image quality metrics on ex vivo mouse brain magnetic resonance images obtained at 16.4 T at various echo times. Four experts also compared the quality of in vivo 1.5 and 3 T human brain magnetic resonance images generated with traditional susceptibility weighted imaging and with the new method. We found that parameters of the modified human contrast sensitivity function can be chosen to improve delineation of structural detail of mouse and human brains. Information contained in susceptibility-weighted images generated using the modified human contrast sensitivity function based phase mask corresponds to that in the conventional method, however the visual range over which it is depicted has improved visual perception. Hence, qualitative evaluation of information contained in susceptibility-weighted images can be improved by amplifying spatial frequencies where human contrast sensitivity is reduced.
Keyword Susceptibility weighted imaging
Phase mask
Phase filtering
Human contrast sensitivity function
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 21 May 2014, 17:24:55 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging