A battle for survival: immune control and immune evasion in murine γ-herpesvirus-68 infection

Stevenson, Philip G., Boname, Jessica M., De Lima, Brigitte and Efstathiou, Stacey (2002) A battle for survival: immune control and immune evasion in murine γ-herpesvirus-68 infection. Microbes and Infection, 4 11: 1177-1182. doi:10.1016/S1286-4579(02)01643-X


Author Stevenson, Philip G.
Boname, Jessica M.
De Lima, Brigitte
Efstathiou, Stacey
Title A battle for survival: immune control and immune evasion in murine γ-herpesvirus-68 infection
Journal name Microbes and Infection   Check publisher's open access policy
ISSN 1286-4579
1769-714X
Publication date 2002-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1286-4579(02)01643-X
Open Access Status Not yet assessed
Volume 4
Issue 11
Start page 1177
End page 1182
Total pages 6
Place of publication Issy les Moulineaux, Cedex, France
Publisher Elsevier Masson
Language eng
Formatted abstract
CD8+ T cells are generally considered a key defence against herpesviruses. The murine γ-herpesvirus-68 encodes two proteins that limit their efficacy. M3 neutralises chemokines, while K3 downregulates MHC class I glycoproteins. The consequence of this evasion is that CD4+ T cells are essential to the control of persistent infection.
Keyword CD8+ T cell
Gammaherpesvirinae
Immune evasion
Interferon-γ
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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