IgG Fc receptors provide an alternative infection route for murine gamma-herpesvirus-68

Rosa, Gustavo T., Gillet, Laurent, Smith, Christopher M., de Lima, Brigitte D. and Stevenson, Philip G. (2007) IgG Fc receptors provide an alternative infection route for murine gamma-herpesvirus-68. PLoS One, 2 6: e560-e560. doi:10.1371/journal.pone.0000560


Author Rosa, Gustavo T.
Gillet, Laurent
Smith, Christopher M.
de Lima, Brigitte D.
Stevenson, Philip G.
Title IgG Fc receptors provide an alternative infection route for murine gamma-herpesvirus-68
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-06-27
Year available 2007
Sub-type Article (original research)
DOI 10.1371/journal.pone.0000560
Open Access Status DOI
Volume 2
Issue 6
Start page e560
End page e560
Total pages 11
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2007
Language eng
Abstract Background. Herpesviruses can be neutralized in vitro but remain infectious immune hosts. One difference betweeh these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor+ cells. Principal Findings. Immune sera blocked murine gamma herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged: but the infection was not abortive and new virus production soon overwhelmed infected cultures, Lyticaily infected macrophages down-related MHC class 1-restricted antigen presentation, endocytosis and their response to LPS. Conclusions. IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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