The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization

Gillet, Laurent, May, Janet S., Colaco, Susanna. and Stevenson, Philip G. (2007) The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization. PLoS One, 2 8: e705-e705. doi:10.1371/journal.pone.0000705


Author Gillet, Laurent
May, Janet S.
Colaco, Susanna.
Stevenson, Philip G.
Title The murine gammaherpesvirus-68 gp150 acts as an immunogenic decoy to limit virion neutralization
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-08-08
Year available 2007
Sub-type Article (original research)
DOI 10.1371/journal.pone.0000705
Open Access Status DOI
Volume 2
Issue 8
Start page e705
End page e705
Total pages 10
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2007
Language eng
Abstract Herpesviruses maintain long-term infectivity without marked antigenic variation. They must therefore evade neutralization by other means, Immune sera block murine gammaherpesvirus-68 (MHV-68) infection of fibroblasts, but fail to block and even enhance its infection of IgG Fc receptor-bearing cells, suggesting that the antibody response to infection is actually poor at ablating virion infectivity completely. Here we analyzed this effect further by quantitating the glycoprotein-specific antibody response of MHV-68 carrier mice. Gp150 was much the commonest glycoprotein target and played a predominant role in driving Fc receptor-dependent infection: when gp150-specific antibodies were boosted, Fc receptor-dependent infection increased; and when gp150-specific antibodies were removed, Fc receptor-dependent infection was largely lost. Neither gp150-specific monoclonal antibodies nor gp150-specific polyclonal sera gave significant virion neutralization. Gp150 therefore acts as an immunogenic decoy, distorting the MHV-68-specific antibody response to promote Fc receptor-dependent infection and so compromise virion neutralization. This immune evasion mechanism may be common to many non-essential herpesvirus glycoproteins.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Clinical Medical Virology Centre Publications
 
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