Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

Guzman-Gutierrez, Enrique, Abarzua, Fernando, Belmar, Cristian, Nien, Jyh K., Ramirez, Marco A., Arroyo, Pablo, Salomon, Carlos, Westermeier, Francisco, Puebla, Carlos, Leiva, Andrea, Casanello, Paola and Sobrevia, Luis (2011) Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes. Current Vascular Pharmacology, 9 6: 750-762. doi:10.2174/157016111797484062


Author Guzman-Gutierrez, Enrique
Abarzua, Fernando
Belmar, Cristian
Nien, Jyh K.
Ramirez, Marco A.
Arroyo, Pablo
Salomon, Carlos
Westermeier, Francisco
Puebla, Carlos
Leiva, Andrea
Casanello, Paola
Sobrevia, Luis
Title Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes
Journal name Current Vascular Pharmacology   Check publisher's open access policy
ISSN 1570-1611
1875-6212
Publication date 2011-11
Sub-type Article (original research)
DOI 10.2174/157016111797484062
Open Access Status
Volume 9
Issue 6
Start page 750
End page 762
Total pages 13
Place of publication Netherlands
Publisher Bentham Science Publishers Ltd
Language eng
Abstract Gestational diabetes mellitus (GDM) is a syndrome compromising the health of the mother and the fetus. Endothelial damage and reduced metabolism of the vasodilator adenosine occur and fetal hyperinsulinemia associated with deficient insulin response and a metabolic rather than mitogenic phenotype is characteristic of this pathology. These phenomena lead to endothelial dysfunction of the fetoplacental unit. Major databases were searched for the relevant literature in the field. Special attention was placed on publications related with diabetes and hormone/metabolic disorders. We aimed to summarize the information regarding insulin sensitivity changes in GDM and the role of adenosine in this phenomenon. Evidence supporting the possibility that fetal endothelial dysfunction involves a functional link between adenosine and insulin signaling in the fetal endothelium from GDM pregnancies is summarized. Since insulin acts via membrane receptors type A (preferentially associated with mitogenic responses) or type B (preferentially associated with metabolic responses), a differential activation of these receptors in this syndrome is proposed.
Keyword Adenosine
endothelium
fetus
gestational diabetes
insulin receptor
placenta
Umbilical Vein Endothelium
Myocardial Blood-Flow
L-Arginine Transport
Slc29A1 Promoter Activity
Smooth-Muscle-Cells
Rat Skeletal-Muscle
Nitric-Oxide
Glucose-Transport
Receptor Isoforms
Cord Plasma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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