Assessing local outcomes in heterogeneous gliomas

Dowson, Nicholas, Thomas, Paul, Gal, Yaniv, Fay, Michael, Jeffree, Rosalind L., Winter, Craig, Coulthard, Alan, Smith, Jye, Bourgeat, Pierrick, Salvado, Olivier, Crozier, Stuart and Rose, Stephen (2014). Assessing local outcomes in heterogeneous gliomas. In: Proceedings of the 17th International Conference on the Use of Computers in Radiation Therapy, ICCR 2013. 17th International Conference on the Use of Computers in Radiation Therapy (ICCR 2013), Melbourne, Australia, (). 6-9 May 2013. doi:10.1088/1742-6596/489/1/012073


Author Dowson, Nicholas
Thomas, Paul
Gal, Yaniv
Fay, Michael
Jeffree, Rosalind L.
Winter, Craig
Coulthard, Alan
Smith, Jye
Bourgeat, Pierrick
Salvado, Olivier
Crozier, Stuart
Rose, Stephen
Title of paper Assessing local outcomes in heterogeneous gliomas
Conference name 17th International Conference on the Use of Computers in Radiation Therapy (ICCR 2013)
Conference location Melbourne, Australia
Conference dates 6-9 May 2013
Proceedings title Proceedings of the 17th International Conference on the Use of Computers in Radiation Therapy, ICCR 2013   Check publisher's open access policy
Journal name Journal of Physics: Conference Series   Check publisher's open access policy
Place of Publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Publication Year 2014
Year available 2014
Sub-type Fully published paper
DOI 10.1088/1742-6596/489/1/012073
Open Access Status DOI
ISSN 1742-6588
1742-6596
Volume 489
Issue 1
Total pages 4
Collection year 2015
Language eng
Abstract/Summary Tumours are known to be heterogeneous, yet typical treatment plans consider them as a single unit. This may influence treatment outcomes. However, treatment cannot be customised to intra-tumour variation without a method to establish outcomes at an intra-tumour scale. This work proposes a method to both assess and measure outcomes locally within tumours. Methods: Four patients were scanned at two post-surgery time points using contrast enhanced MRI and 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine (18F-DOPA) PET. The shell of active tumour tissue is divided into a set of small subregions at both time points. Local outcome is measured from changes in subregion volume over time. The utility of the proposed approach is evaluated by measuring the correlation between PET uptake and documented growth. Correlation with overall survival time was also examined. Results: Local outcomes were heterogeneous and evidence of a positive correlation between local 18F-DOPA uptake and local progression was observed. Conclusions: Given that intra-tumour outcomes are heterogeneous the consistently positive correlation between FDOPA uptake and progression, local analysis of tumours could prove useful for treatment planning.
Subjects 3100 Physics and Astronomy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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