Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: Their evaluation as novel and potential insulin secretagogues

Reddy, Seelam Venkata, Rao, Gangula Mohan, Kumar, Baru Vijaya, Reddy, Koppela Naresh, Sravya, Konda, Goverdhan, Puchchakayala, Rathore, Vandana, Deora, Girdhar Singh and Pal, Manojit (2014) Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: Their evaluation as novel and potential insulin secretagogues. MedChemComm, 5 5: 587-592. doi:10.1039/c3md00377a


Author Reddy, Seelam Venkata
Rao, Gangula Mohan
Kumar, Baru Vijaya
Reddy, Koppela Naresh
Sravya, Konda
Goverdhan, Puchchakayala
Rathore, Vandana
Deora, Girdhar Singh
Pal, Manojit
Title Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: Their evaluation as novel and potential insulin secretagogues
Journal name MedChemComm   Check publisher's open access policy
ISSN 2040-2511
2040-2503
Publication date 2014
Sub-type Article (original research)
DOI 10.1039/c3md00377a
Open Access Status
Volume 5
Issue 5
Start page 587
End page 592
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2015
Language eng
Abstract A series of N-(alkyl/aryl/heteroaryl)-1-nitro-10H-phenoxazine-3- sulfonamides was designed, synthesized and evaluated for its hypoglycemic, hyperglycemic and oral anti-diabetic activities. These compounds were prepared via the construction of a phenoxazine ring containing nitro and sulfonic acid groups in a single step followed by further transformations. One of these compounds exhibited promising anti-diabetic activities comparable to glibenclamide and increased serum insulin levels indicating its potential as a novel insulin secretagogue. This journal is
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
 
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