Can we move towards personalised pancreatic cancer therapy?

Jamieson, Nigel Balfour, Chang, David K., Grimmond, Sean M. and Biankin, Andrew V. (2014) Can we move towards personalised pancreatic cancer therapy?. Expert Review of Gastroenterology and Hepatology, 8 4: 335-338. doi:10.1586/17474124.2014.893820


Author Jamieson, Nigel Balfour
Chang, David K.
Grimmond, Sean M.
Biankin, Andrew V.
Title Can we move towards personalised pancreatic cancer therapy?
Journal name Expert Review of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 1747-4124
1747-4132
Publication date 2014
Year available 2014
Sub-type Editorial
DOI 10.1586/17474124.2014.893820
Open Access Status DOI
Volume 8
Issue 4
Start page 335
End page 338
Total pages 4
Place of publication London, United Kingdom
Publisher Expert Reviews Ltd.
Collection year 2015
Language eng
Subject 2721 Hepatology
2715 Gastroenterology
Abstract Pancreatic ductal adenocarcinoma remains an unyielding adversary, with a 5-year survival of 5%, a figure unchanged in 50 years. Characterised by marked genetic heterogeneity, recent genomic sequencing efforts demonstrate that with the exclusion of a few known mutations, most mutations occur at a prevalence of <5%. Current systemic chemotherapeutics, when used in an all-comer approach, are at best modestly effective, yet are associated with responses in small groups of undefined patients. Defining these subgroups and targeting them with the appropriate therapy in a personalized or stratified approach holds the promise of improved outcomes for this disease.
Keyword Actionable phenotypes
Genomics
Pancreatic Cancer
Sequencing
Stratified medicine
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collection: Institute for Molecular Bioscience - Publications
 
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