Pd/C-mediated arylation followed by I2-catalyzed hydration strategy: Preparation of functionalized novel indanone derivatives

Dulla B., Kolli S.K., Chamakura U.R., Deora G.S., Raju R.R. and Pal M. (2014) Pd/C-mediated arylation followed by I2-catalyzed hydration strategy: Preparation of functionalized novel indanone derivatives. Synthetic Communications, 44 10: 1466-1474. doi:10.1080/00397911.2013.860554


Author Dulla B.
Kolli S.K.
Chamakura U.R.
Deora G.S.
Raju R.R.
Pal M.
Title Pd/C-mediated arylation followed by I2-catalyzed hydration strategy: Preparation of functionalized novel indanone derivatives
Formatted title
Pd/C-mediated arylation followed by I2-catalyzed hydration strategy: Preparation of functionalized novel indanone derivatives
Journal name Synthetic Communications   Check publisher's open access policy
ISSN 1532-2432
0039-7911
Publication date 2014-05-19
Year available 2014
Sub-type Article (original research)
DOI 10.1080/00397911.2013.860554
Open Access Status
Volume 44
Issue 10
Start page 1466
End page 1474
Total pages 9
Place of publication New York, NY United States
Publisher Taylor & Francis
Collection year 2015
Language eng
Formatted abstract
A simple and inexpensive synthesis of novel 2-(3-oxo-3-arylpropyl)-2,3- dihydro-1H-inden-1-one derivatives has been achieved via Pd/C-mediated arylation followed by I2-mediated regioselective hydration of 2-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-ones. A wide variety of 3-aryl substituted 2-propynyl indanone derivatives were conveniently prepared by using 10% Pd/C-PPh3-CuI as a catalyst system, some of which were used to prepare the corresponding ketones via alkyne hydration in the presence of catalytic I2. In an in vitro study a representative compound showed inhibition of PDE4B (phosphodiesterase type 4B) and binding with this protein in silico
Keyword Alkyne
Hydration
Indanone
Iodine
Pd/C
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
 
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