RNA-binding proteins in neurological diseases

Zhou, HuaLin, Mangelsdorf, Marie, Liu, JiangHong, Zhu, Liu and Wu, Jane Y. (2014) RNA-binding proteins in neurological diseases. Science China Life Sciences, 57 4: 432-444. doi:10.1007/s11427-014-4647-9


Author Zhou, HuaLin
Mangelsdorf, Marie
Liu, JiangHong
Zhu, Liu
Wu, Jane Y.
Title RNA-binding proteins in neurological diseases
Journal name Science China Life Sciences   Check publisher's open access policy
ISSN 1674-7305
1869-1889
Publication date 2014-03-21
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11427-014-4647-9
Open Access Status DOI
Volume 57
Issue 4
Start page 432
End page 444
Total pages 13
Place of publication Beijing, China
Publisher Science China Press
Collection year 2015
Language eng
Subject 2300 Environmental Science
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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