Identification of neurons responsible for feeding behavior in the Drosophila brain

Sun, Fei, Wang, YiJin, Zhou, YanQiong, Van Swinderen, Bruno, Gong, ZheFeng and Liu, Li (2014) Identification of neurons responsible for feeding behavior in the Drosophila brain. Science China-Life Sciences, 57 4: 391-402. doi:10.1007/s11427-014-4641-2


Author Sun, Fei
Wang, YiJin
Zhou, YanQiong
Van Swinderen, Bruno
Gong, ZheFeng
Liu, Li
Title Identification of neurons responsible for feeding behavior in the Drosophila brain
Formatted title
Identification of neurons responsible for feeding behavior in the Drosophila brain
Journal name Science China-Life Sciences   Check publisher's open access policy
ISSN 1674-7305
1869-1889
Publication date 2014-04
Sub-type Article (original research)
DOI 10.1007/s11427-014-4641-2
Open Access Status DOI
Volume 57
Issue 4
Start page 391
End page 402
Total pages 12
Place of publication Beijing, China
Publisher Science in China Press
Collection year 2015
Language eng
Formatted abstract
Drosophila melanogaster feeds mainly on rotten fruits, which contain many kinds of sugar. Thus, the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior. Although several sugar receptors have been described, it remains poorly understood how the sensory input is transformed into an appetitive behavior. Here, we used a neural silencing approach to screen brain circuits, and identified neurons labeled by three Gal4 lines that modulate Drosophila feeding behavior. These three Gal4 lines labeled neurons mainly in the suboesophageal ganglia (SOG), which is considered to be the fly’s primary taste center. When we blocked the activity of these neurons, flies decreased their sugar consumption significantly. In contrast, activation of these neurons resulted in enhanced feeding behavior and increased food consumption not only towards sugar, but to an array of food sources. Moreover, upon neuronal activation, the flies demonstrated feeding behavior even in the absence of food, which suggests that neuronal activation can replace food as a stimulus for feeding behavior. These findings indicate that these Gal4-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control.
Keyword Feeding behavior
Sugar-sensing neurons
SOG
CAFE assay
Proboscis extension response (PER)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Created: Sun, 18 May 2014, 00:04:08 EST by System User on behalf of Queensland Brain Institute