Disruption of structure-function coupling in the schizophrenia connectome

Cocchi, Luca, Harding, Ian H., Lord, Anton, Pantelis, Christos, Yucel, Murat and Zalesky, Andrew (2014) Disruption of structure-function coupling in the schizophrenia connectome. NeuroImage: Clinical, 4 779-787. doi:10.1016/j.nicl.2014.05.004

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Author Cocchi, Luca
Harding, Ian H.
Lord, Anton
Pantelis, Christos
Yucel, Murat
Zalesky, Andrew
Title Disruption of structure-function coupling in the schizophrenia connectome
Journal name NeuroImage: Clinical   Check publisher's open access policy
ISSN 2213-1582
Publication date 2014-05-09
Sub-type Article (original research)
DOI 10.1016/j.nicl.2014.05.004
Open Access Status DOI
Volume 4
Start page 779
End page 787
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Highlights
• Relationship between functional and structural connectivity tested in schizophrenia
• Convergent functional and structural deficits in fronto-temporo-subcortical network
• Additional loss of association between function and structure defines this network.
• Impaired structural integrity may lead to less constraint of functional activity.
• Abnormal principles of brain organization may define core networks of pathology.

Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functional and structural brain networks. However, the relationship between structural and functional deficits remains unclear. To answer this question, patients with established schizophrenia and matched healthy controls underwent resting-state functional and diffusion weighted imaging. The network-based statistic was used to characterize between-group differences in whole-brain functional connectivity. Indices of white matter integrity were then estimated to assess the structural correlates of the functional alterations observed in patients. Finally, group differences in the relationship between indices of functional and structural brain connectivity were determined. Compared to controls, patients with schizophrenia showed decreased functional connectivity and impaired white matter integrity in a distributed network encompassing frontal, temporal, thalamic, and striatal regions. In controls, strong interregional coupling in neural activity was associated with well-myelinated white matter pathways in this network. This correspondence between structure and function appeared to be absent in patients with schizophrenia. In two additional disrupted functional networks, encompassing parietal, occipital, and temporal cortices, the relationship between function and structure was not affected. Overall, results from this study highlight the importance of considering not only the separable impact of functional and structural connectivity deficits on the pathoaetiology of schizophrenia, but also the implications of the complex nature of their interaction. More specifically, our findings support the core nature of fronto-striatal, fronto-thalamic, and fronto-temporal abnormalities in the schizophrenia connectome.
Keyword Brain connectivity
fMRI
Diffusion
DTI
Psychosis
Resting state
Structure-function
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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Created: Tue, 13 May 2014, 13:19:55 EST by Luca Cocchi on behalf of Queensland Brain Institute