EBC-219: a new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridgehead double bond

Maslovskaya, Lidiya A., Savchenko, Andrei I., Krenske, Elizabeth H., Pierce, Carly J., Gordon, Victoria A., Reddell, Paul W., Parsons, Peter G. and Williams, Craig M. (2014) EBC-219: a new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridgehead double bond. Angewandte Chemie, 126 27: 7126-7129. doi:10.1002/ange.201310923

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Author Maslovskaya, Lidiya A.
Savchenko, Andrei I.
Krenske, Elizabeth H.
Pierce, Carly J.
Gordon, Victoria A.
Reddell, Paul W.
Parsons, Peter G.
Williams, Craig M.
Title EBC-219: a new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridgehead double bond
Journal name Angewandte Chemie   Check publisher's open access policy
ISSN 0044-8249
1521-3757
Publication date 2014-05-05
Sub-type Article (original research)
DOI 10.1002/ange.201310923
Volume 126
Issue 27
Start page 7126
End page 7129
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Collection year 2015
Language eng
Formatted abstract
EBC-219 (4), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co-isolated natural products EBC-131 (1), EBC-180 (2) and EBC-181 (3) is highly likely. EBC-180 (2) and EBC-181 (3) showed moderate to strong cytotoxic activity against various cancer cell lines.
Keyword Brückenkopfolefine
Crotinsulidane
EBC-219
Naturstoffe
Strukturaufklärung
Brueckenkopfolefine
Strukturaufklaerung
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 5 MAY 2014. Dedicated to Professor Armin de Meijere on the occasion of his 75th birthday.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
 
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Created: Fri, 09 May 2014, 13:23:10 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences