Wet Granule Breakage in a High Shear Mixer

Suhairi, Nurul Nazleen (2006). Wet Granule Breakage in a High Shear Mixer Honours Thesis, School of Engineering, The University of Queensland.

       
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Author Suhairi, Nurul Nazleen
Thesis Title Wet Granule Breakage in a High Shear Mixer
School, Centre or Institute School of Engineering
Institution The University of Queensland
Publication date 2006
Thesis type Honours Thesis
Supervisor Lian Liu
Jim Litster
Total pages 68
Language eng
Subjects 09 Engineering
0904 Chemical Engineering
Formatted abstract
Forty-two granulation experiments were performed in a high-shear mixer at various residence times, binders and powders in order to

  1. Briefly evaluate the mechanisms involve in granulation processes;
  2. Relate the granule properties and characterisation in determining the granule strength;
  3. Improve the experimental methods in studying wet granule breakage in high shear mixer;
  4. Observe granule deformation behaviour associated to different binder saturation value;
  5. Control the granule properties which include shape, porosity and powder distribution size in order to minimise variability in determining wet granule breakage behaviour;
  6. Study the influence of granule properties and process variables on the wet granule breakage in a high shear mixer; and
  7. Study the effect of
     i. binder saturation,
     ii. binder viscosity, and
     iii. residence time
   on breakage behaviour based on experimental observation.

Recommendation on future research on wet granule breakage study will include:

♦ Larger range of binder viscosity is required in order to characterise the breakage behaviour with binder viscosity effect
♦ More variation of powder used to account for the effect for primary particle size
♦ The usage of saturated broad lactose in order to study the behaviour of broad lactose with water as the binder
♦ Varying impeller speed and shape of blade in order to investigate the influence of process variables towards wet granule breakage
♦ Repeat the work that were previously done to put into account the error bars associated to each measurement
Keyword High Shear Mixer

Document type: Thesis
Collection: UQ Theses (non-RHD) - UQ staff and students only
 
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Created: Wed, 07 May 2014, 11:56:03 EST by Ahmed Taha Siddiqui on behalf of Scholarly Communication and Digitisation Service