Proteogenomic characterisation of circulating acute phase markers and bioassay development in sheep

Chemonges, Saul (2014). Proteogenomic characterisation of circulating acute phase markers and bioassay development in sheep. In: 2014 Diamantina Health Partners 2nd Annual Forum. Pre-Forum Symposium: Research and Innovation Ideas Awards, Woolloongabba, QLD, Australia, (1-1). 30 April-2 May, 2014.

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Author Chemonges, Saul
Title of paper Proteogenomic characterisation of circulating acute phase markers and bioassay development in sheep
Conference name 2014 Diamantina Health Partners 2nd Annual Forum. Pre-Forum Symposium: Research and Innovation Ideas Awards
Conference location Woolloongabba, QLD, Australia
Conference dates 30 April-2 May, 2014
Publication Year 2014
Sub-type Published abstract
Open Access Status
Start page 1
End page 1
Total pages 1
Language eng
Formatted Abstract/Summary
Background: Relevant large animal models are essential in translational research. Recent observations show that some sheep appear to be more susceptible to the effects of Escherichia coli lipopolysaccharide (LPS) endotoxin than others, despite having the same characteristics. The reason behind this difference is unknown and has prompted studies aiming to explain the variation by proteogenomic characterisation of endotoxin-induced circulating acute phase biomarkers. It is hypothesised that lifestyle, genetic trait, biochemical, immunological and inflammation marker patterns contribute in defining and predicting mammalian response to LPS

Methods: Backgrounds of sheep enrolled in a primary study with an important translational focus that showed selective resistance to endotoxin were investigated. Data on animal sources, production traits, management and preventive health practices were analysed.

Results: Endotoxin resistant sheep had been raised on open pasture and had a different vendor. Susceptible sheep were from a government controlled scientific breeding colony with either wool or endoparasite resistance trait.

Conclusion: Not all experimental sheep are the same. Proteogenomic study approaches may help to understand the mechanisms of selection to LPS morbidity in sheep and similar pathology in humans.
Keyword Proteogenomics
Sheep
Lipopolysaccharide (LPS)
Large animal models
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Tue, 06 May 2014, 16:17:03 EST by Saul Chemonges on behalf of School of Medicine