A Murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread

Frederico, B., Chao, B., May, J.S., Belz, G.T. and Stevenson, P.G. (2014) A Murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread. Cell Host and Microbe, 15 4: 457-470. doi:10.1016/j.chom.2014.03.010


Author Frederico, B.
Chao, B.
May, J.S.
Belz, G.T.
Stevenson, P.G.
Title A Murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread
Journal name Cell Host and Microbe   Check publisher's open access policy
ISSN 1934-6069
1931-3128
Publication date 2014-04-09
Sub-type Article (original research)
DOI 10.1016/j.chom.2014.03.010
Open Access Status
Volume 15
Issue 4
Start page 457
End page 470
Total pages 14
Place of publication Cambridge, MA, U.S.A.
Publisher Cell Press
Collection year 2015
Language eng
Subject 2400 Immunology and Microbiology
1306 Cancer Research
1312 Molecular Biology
Abstract Gamma-herpesviruses (γHVs) are widespread oncogenic pathogens that chronically infect circulating lymphocytes. How they subvert the immune check-point function of the spleen to promote persistent infection is not clear. We show that Murid Herpesvirus-4 (MuHV-4) enters the spleen by infecting marginal zone (MZ) macrophages, which provided a conduit to MZ B cells. Relocation of MZ B cells to the white pulp allowed virus transfer to follicular dendritic cells. From here the virus reached germinal center B cells to establish persistent infection. Mice lacking MZ B cells, or treated with a sphingosine-1-phosphate receptor agonist to dislocate them, were protected against MuHV-4 colonization. MuHV-4 lacking ORF27, which encodes a glycoprotein necessary for efficient intercellular spread, could infect MZ macrophages but was impaired in long-term infection. Thus, MuHV-4, a γHV, exploits normal immune communication routes to spread by serial lymphoid/myeloid exchange.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
 
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