Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation

Srivatsa, Swathi, Parthasarathy, Srinivas, Britanova, Olga, Bormuth, Ingo, Donahoo, Amber-Lee, Ackerman, Susan L., Richards, Linda J. and Tarabykin, Victor (2014) Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. Nature Communications, 5 . doi:10.1038/ncomms4708


Author Srivatsa, Swathi
Parthasarathy, Srinivas
Britanova, Olga
Bormuth, Ingo
Donahoo, Amber-Lee
Ackerman, Susan L.
Richards, Linda J.
Tarabykin, Victor
Title Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2014-04-17
Year available 2014
Sub-type Article (original research)
DOI 10.1038/ncomms4708
Open Access Status DOI
Volume 5
Total pages 14
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1600 Chemistry
3100 Physics and Astronomy
Abstract The pyramidal neurons of the mammalian neocortex form two major types of long-range connections-corticocortical and cortico-subcortical. The transcription factors Satb2 and Ctip2 are critical regulators of neuronal cell fate that control interhemispheric versus corticofugal connections respectively. Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 that establish these connections. We show that the expression of two Netrin1 receptors-DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively. Further, we show that the Netrin1-Unc5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Biomedical Sciences Publications
 
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