Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox

Lavie, Carl J., McAuley, Paul A., Church, Timothy S., Milani, Richard V. and Blair, Steven N. (2014) Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. Journal of the American College of Cardiology, 63 14: 1345-1354. doi:10.1016/j.jacc.2014.01.022

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Author Lavie, Carl J.
McAuley, Paul A.
Church, Timothy S.
Milani, Richard V.
Blair, Steven N.
Title Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
ISSN 1558-3597
0735-1097
Publication date 2014-04-15
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jacc.2014.01.022
Open Access Status File (Author Post-print)
Volume 63
Issue 14
Start page 1345
End page 1354
Total pages 10
Place of publication San Diego, CA, United States
Publisher Elsevier
Collection year 2015
Language eng
Abstract Obesity has been increasing in epidemic proportions, with a disproportionately higher increase in morbid or class III obesity, and obesity adversely affects cardiovascular (CV) hemodynamics, structure, and function, as well as increases the prevalence of most CV diseases. Progressive declines in physical activity over 5 decades have occurred and have primarily caused the obesity epidemic. Despite the potential adverse impact of overweight and obesity, recent epidemiological data have demonstrated an association of mild obesity and, particularly, overweight on improved survival. We review in detail the obesity paradox in CV diseases where overweight and at least mildly obese patients with most CV diseases seem to have a better prognosis than do their leaner counterparts. The implications of cardiorespiratory fitness with prognosis are discussed, along with the joint impact of fitness and adiposity on the obesity paradox. Finally, in light of the obesity paradox, the potential value of purposeful weight loss and increased physical activity to affect levels of fitness is reviewed.
Keyword Cardiovascular disease
Fitness
Obesity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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