Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma

Seidl H., Richtig E., Tilz H., Stefan M., Schmidbauer U., Asslaber M., Zatloukal K., Herlyn M. and Schaider H. (2007) Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma. Human Pathology, 38 5: 768-780. doi:10.1016/j.humpath.2006.11.013

Author Seidl H.
Richtig E.
Tilz H.
Stefan M.
Schmidbauer U.
Asslaber M.
Zatloukal K.
Herlyn M.
Schaider H.
Title Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma
Journal name Human Pathology   Check publisher's open access policy
ISSN 0046-8177
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.humpath.2006.11.013
Volume 38
Issue 5
Start page 768
End page 780
Total pages 13
Language eng
Subject 2734 Pathology and Forensic Medicine
Abstract Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue samples investigating the expression of 18 chemokine receptors at the mRNA level by real-time polymerase chain reaction, using a semiquantitative approach, and of 3 chemokine receptors (CXCR6, CCR9, and XCR1) at the protein level. We report on the de novo expression of CXCR6 in primary melanomas and melanoma metastases, but absence in melanoma cell lines and congenital nevi. CXCR4 and CCR1 were the only 2 chemokine receptors that were consistently expressed in melanocytes, melanoma cell lines, primary, and metastatic melanoma; CCR1 expression increased significantly over progression. CCR9 and XCR1 transcripts were found in melanocytic lesions, and expression was confirmed by immunohistochemistry. Transcripts for CCR10 were not found in any of the lesions, but in some melanoma cell lines. Expression of CCR7 was observed in primary melanomas and some metastases. CCR5 was exclusively expressed in primary melanomas and some cutaneous metastases. Results revealed a restricted and differential pattern of chemokine receptor expression in melanoma tissue, which varies substantially from the expression profile of melanoma cell lines and warrants functional studies on some receptors.
Keyword Chemokine
Chemokine receptor
Malignant melanoma
Tumor progression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
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