Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients

Gutwein, Paul, Schramme, Anja, Sinke, Nina, Abdel-Bakky, Mohamed Sadek, Voss, Beren, Obermuller, Nicholas, Doberstein, Kai, Koziolek, Michael, Fritzsche, Florian, Johannsen, Manfred, Jung, Klaus, Schaider, Helmut, Altevogt, Peter, Ludwig, Andreas, Pfeilschifter, Josef and Kristiansen, Glen (2009) Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. European Journal of Cancer, 45 3: 478-489. doi:10.1016/j.ejca.2008.10.023


Author Gutwein, Paul
Schramme, Anja
Sinke, Nina
Abdel-Bakky, Mohamed Sadek
Voss, Beren
Obermuller, Nicholas
Doberstein, Kai
Koziolek, Michael
Fritzsche, Florian
Johannsen, Manfred
Jung, Klaus
Schaider, Helmut
Altevogt, Peter
Ludwig, Andreas
Pfeilschifter, Josef
Kristiansen, Glen
Title Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
1879-0852
Publication date 2009
Sub-type Article (original research)
DOI 10.1016/j.ejca.2008.10.023
Open Access Status
Volume 45
Issue 3
Start page 478
End page 489
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract The aim of our study was to analyse the expression of CXCL16, ADAM10 and CXCR6 in renal cell carcinoma (RCC) tissue and to correlate the expression pattern with clinicopathologic data, including patient survival. Furthermore, we investigated CXCL16, ADAM10 and CXCR6 expressions by FACS, immunofluorescence and ELISA analysis in renal carcinoma cell lines. Our immunohistochemical analysis on tissue microarray of renal cancer samples of 104 patients revealed that ADAM10 correlated significantly with tumour stage, pathological nodal status, M status and lymphangiosis carcinomatosa. CXCL16, CXCR6 and ADAM10 were significantly increased in papillary carcinomas. Importantly, high levels of CXCL16 expression in renal cancer tissue correlated with better survival of patients, and CXCL16 correlated inversely to the tumour stage. In addition, inhibition of CXCL16 induced the migration of renal cancer cells assuming an anti-migratory function of transmembrane CXCL16. Taken together, our data demonstrate that downregulation of CXCL16 plays an important role in renal cancer development and progression, and that CXCL16 in RCC is an independent prognostic marker for better patient survival.
Keyword ADAM10
CXCL16
CXCR6
Renal cancer
Renal cancer tissue
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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