Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma cells

Kretschmer, Nadine, Rinner, Beate, Deutsch, Alexander J. A., Lohberger, Birgit, Knausz, Heike, Kunert, Olaf, Blunder, Martina, Boechzelt, Herbert, Schaider, Helmut and Bauer, Rudolf (2012) Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma cells. Journal of Natural Products, 75 5: 865-869. doi:10.1021/np2006499


Author Kretschmer, Nadine
Rinner, Beate
Deutsch, Alexander J. A.
Lohberger, Birgit
Knausz, Heike
Kunert, Olaf
Blunder, Martina
Boechzelt, Herbert
Schaider, Helmut
Bauer, Rudolf
Title Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma cells
Formatted title
Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma cells 
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2012-05-25
Sub-type Article (original research)
DOI 10.1021/np2006499
Open Access Status
Volume 75
Issue 5
Start page 865
End page 869
Total pages 5
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract Activity-guided fractionation of a petroleum ether-soluble extract of the roots of Onosma paniculata, which has been shown to affect the cell cycle and to induce apoptosis in melanoma cells, led to the isolation of several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), and a mixture of α-methylbutyrylshikonin and isovalerylshikonin (4+5). All compounds exhibited strong cytotoxicity against eight cancer cell lines and MRC-5 lung fibroblasts, with 3 found to possess the most potent cytotoxicity toward four melanoma cell lines (SBcl2, WM35, WM9, and WM164). Furthermore, 3 and the mixture of 4+5 were found to interfere with cell-cycle progression in these cell lines and led to an increasing number of cells in the subG1 region as well as to caspase-3/7 activation, indicating apoptotic cell death.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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