Synthesis, spectroscopy and X-ray crystal structures of some zinc(II) and cadmium(II) complexes of the 2-pyridinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates

Mirza, Aminul Huq, Hamid, Malai Haniti S. A., Aripin, Sazwani, Karim, Mohammad Rezaul, Arifuzzaman, Md., Ali, Mohammad Akbar and Bernhardt, Paul V. (2014) Synthesis, spectroscopy and X-ray crystal structures of some zinc(II) and cadmium(II) complexes of the 2-pyridinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates. Polyhedron, 74 16-23. doi:10.1016/j.poly.2014.02.016


Author Mirza, Aminul Huq
Hamid, Malai Haniti S. A.
Aripin, Sazwani
Karim, Mohammad Rezaul
Arifuzzaman, Md.
Ali, Mohammad Akbar
Bernhardt, Paul V.
Title Synthesis, spectroscopy and X-ray crystal structures of some zinc(II) and cadmium(II) complexes of the 2-pyridinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates
Journal name Polyhedron   Check publisher's open access policy
ISSN 0277-5387
1873-3719
Publication date 2014-05-28
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.poly.2014.02.016
Open Access Status
Volume 74
Start page 16
End page 23
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2015
Language eng
Formatted abstract
The Schiff bases formed by condensation of S-methyl- and S-benzyldithiocarbazate with 2-pyridinecarboxaldehyde react with zinc(II) and cadmium(II) acetates to form stable metal complexes of general formulas, [Zn(NNS)(CH3COO)]2 and [M(NNS)2] (M = Zn 2+, Cd2+; NNS- = anionic forms of the 2-pyridinecarboxaldenhdye. Schiff bases of S-methyl- and S-benzyldithiocarbazate, respectively) which have been characterized by a variety of physico-chemical techniques and X-ray crystallographic structure analysis. The complexes, [Zn(NNS)(CH3COO)]2 are acetate anion-bridged centrosymmetric dimers in which each of the Schiff bases is coordinated to the zinc(II) ions as a uninegatively charged NNS tridentate chelating agent coordinating via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulfur atom. The acetate anion acts as a bridging bidentate ligand coordinating with the two zinc atoms in a syn-syn manner. Each zinc(II) ion in the dimer adopts an approximately square-pyramidal geometry. The bis-ligand complexes, [M(NNS)2] (M = Zn2+, Cd2+) have distorted octahedral structures in which the two anionic Schiff bases are coordinated to the metal ions meridionally as NNS tridentate chelating agents via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulfur atom. Both the mono- and bis-ligand zinc(II) complexes exhibit strong cytotoxic activity against the HELA (human cervical cancer) cell lines. Some of these compounds exhibit stronger cytotoxicity against HELA than the commercially important anticancer drug, Tamoxifen.
Keyword Zinc(II) and cadmium(II) complexes of Schiff bases
2-Pyridinecarboxaldehyde Schiff bases of S-methyl- and S-benzyldithiocarbazates
Acetate-bridged dimer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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