Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care

Chemonges, Saul, Shekar, Kiran, Tung, John-Paul, Dunster, Kimble R., Diab, Sara, Platts, David, Watts, Ryan P., Gregory, Shaun D., Foley, Samuel, Simonova, Gabriela, McDonald, Charles, Hayes, Rylan, Bellpart, Judith, Timms, Daniel, Chew, Michelle, Fung, Yoke L., Toon, Michael, Maybauer, Marc O. and Fraser, John F. (2014) Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. BioMed Research International, 2014 468309: 1-17. doi:10.1155/2014/468309

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Author Chemonges, Saul
Shekar, Kiran
Tung, John-Paul
Dunster, Kimble R.
Diab, Sara
Platts, David
Watts, Ryan P.
Gregory, Shaun D.
Foley, Samuel
Simonova, Gabriela
McDonald, Charles
Hayes, Rylan
Bellpart, Judith
Timms, Daniel
Chew, Michelle
Fung, Yoke L.
Toon, Michael
Maybauer, Marc O.
Fraser, John F.
Title Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
Journal name BioMed Research International   Check publisher's open access policy
ISSN 2314-6133
2314-6141
Publication date 2014-03-25
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2014/468309
Open Access Status DOI
Volume 2014
Issue 468309
Start page 1
End page 17
Total pages 17
Editor Izumi Takeyoshi
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Collection year 2015
Language eng
Formatted abstract
Animal models of critical illness are vital in biomedical research. They provide possibilities for the investigation of pathophysiological processes that may not otherwise be possible in humans. In order to be clinically applicable, the model should simulate the critical care situation realistically, including anaesthesia, monitoring, sampling, utilising appropriate personnel skill mix, and therapeutic interventions. There are limited data documenting the constitution of ideal technologically advanced large animal critical care practices and all the processes of the animal model. In this paper, we describe the procedure of animal preparation, anaesthesia induction and maintenance, physiologic monitoring, data capture, point-of-care technology, and animal aftercare that has been successfully used to study several novel ovine models of critical illness. The relevant investigations are on respiratory failure due to smoke inhalation, transfusion related acute lung injury, endotoxin-induced proteogenomic alterations, haemorrhagic shock, septic shock, brain death, cerebral microcirculation, and artificial heart studies. We have demonstrated the functionality of monitoring practices during anaesthesia required to provide a platform for undertaking systematic investigations in complex ovine models of critical illness.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 10 Apr 2014, 12:07:05 EST by Saul Chemonges on behalf of School of Medicine