Grandparent donors in paediatric renal transplantation

Simpson C.M., McTaggart S.J., Sterne J.A.C., Walker R.G., Powell H.R. and Jones C.L. (2005) Grandparent donors in paediatric renal transplantation. Pediatric Nephrology, 20 11: 1636-1641. doi:10.1007/s00467-005-2002-x


Author Simpson C.M.
McTaggart S.J.
Sterne J.A.C.
Walker R.G.
Powell H.R.
Jones C.L.
Title Grandparent donors in paediatric renal transplantation
Journal name Pediatric Nephrology   Check publisher's open access policy
ISSN 0931-041X
Publication date 2005
Sub-type Article (original research)
DOI 10.1007/s00467-005-2002-x
Open Access Status
Volume 20
Issue 11
Start page 1636
End page 1641
Total pages 6
Language eng
Subject 2727 Nephrology
2735 Pediatrics, Perinatology, and Child Health
Abstract The outcome of transplantation from grandparent donors in comparison with parental donors in paediatric renal transplantation was evaluated in 53 living related donor (LRD) transplantations performed between January 1996 and August 2003. The donor in 13 cases (25%) was a grandparent (Gpar group), and the remaining donors formed the parent group (Par group). The median age of recipients in the Gpar group was 2.75 (1.7-10.6) years and in the Par group was 12.75 (2.4-22) years (P<0.0001). There was no evidence of a difference in patient and graft survival, glomerular filtration rate (GFR) after transplantation, or the number of biopsy proven episodes of rejection between the groups. Doses of prednisolone in the first year following transplantation were greater in recipients from Gpar donors, but the other immunosuppression doses were similar. The median age of donors in the Gpar group was 56 (50-67) years and in the Par group was 41 (27-58) years (P<0.0001). There was no evidence of a difference between the two donor groups in mean creatinine clearance at last follow-up. There were two major donor complications in the Gpar group and one in the Par group. There was no evidence that the length of stay differed between the two groups in either the donors or recipients. These results support the use of carefully selected healthy grandparents as LRDs in children. This option potentially allows for the use of parent donors for a subsequent transplantation.
Keyword Grandparent kidney donors
Living related kidney donors
Paediatric kidney transplant
Parent kidney donors
Transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

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Sub-type: Article (original research)
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