Next generation sequencing and its application in deciphering head and neck cancer

Jessri, Maryam and Farah, Camile S. (2014) Next generation sequencing and its application in deciphering head and neck cancer. Oral Oncology, 50 4: 247-253. doi:10.1016/j.oraloncology.2013.12.017


Author Jessri, Maryam
Farah, Camile S.
Title Next generation sequencing and its application in deciphering head and neck cancer
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
1879-0593
Publication date 2014-04
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.oraloncology.2013.12.017
Open Access Status
Volume 50
Issue 4
Start page 247
End page 253
Total pages 7
Place of publication Bromley, United Kingdom
Publisher Elsevier Ltd
Collection year 2015
Language eng
Formatted abstract
 Head and neck squamous cell carcinoma (HNSCC) are a group of heterogeneous tumours mainly attributable to tobacco use, alcohol consumption and infection with human papillomavirus. Based on the stage of cancer at the time of diagnosis, patients are managed by surgery, radiotherapy, chemotherapy or a combination of these. Early diagnosis usually improves patient prognosis.

Since their first commercial application in 2005, next generation sequencing (NGS) platforms are rapidly changing the face of basic science laboratories; however prior to progressing to clinical applications, clinicians should carefully examine currently available data and guidelines for technical and ethical matters concerning NGS. In this review, we compare various commercially available NGS platforms, with special consideration given to their clinical application in the management of HNSCC.
Keyword Head and neck cancer
Oral cancer
Next generation sequencing
Personalized cancer therapy
Squamous cell carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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