Injectable chitosan hydrogels for localised cancer therapy

Ta, Hang Thu, Dass, Crispin R. and Dunstan, Dave E. (2008) Injectable chitosan hydrogels for localised cancer therapy. Journal of Controlled Release, 126 3: 205-216. doi:10.1016/j.jconrel.2007.11.018


Author Ta, Hang Thu
Dass, Crispin R.
Dunstan, Dave E.
Title Injectable chitosan hydrogels for localised cancer therapy
Journal name Journal of Controlled Release   Check publisher's open access policy
ISSN 0168-3659
1873-4995
Publication date 2008-03-20
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jconrel.2007.11.018
Open Access Status
Volume 126
Issue 3
Start page 205
End page 216
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 3003 Pharmaceutical Science
Abstract The pace of development of delivery systems that could target drugs to specific body sites and control the release of drugs for prolonged periods of time have been steady though slow. Till a decade ago, mostly microspheres or nanoparticles were widely studied and applied in cancer treatment. However, due to shortcomings of these systems, there has been a surge in interest for in situ hydrogels. This review focuses on the current use of injectable in situ chitosan hydrogels in cancer treatment. Formulation protocols for in situ hydrogel systems, their cytotoxic properties, loading and in vitro release of drugs, their effect on cell growth in vitro and inhibition of tumor growth in vivo using mouse models, and future directions to enhance this technology are discussed.
Keyword Cancer
Chitosan
Controlled release
Drug delivery
Hydrogel
Therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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