Chitosan-dibasic orthophosphate hydrogel: a potential drug delivery system

Ta, Hang T., Han, Han, Larson, Ian, Dass, Crispin R. and Dunstan, Dave E. (2009) Chitosan-dibasic orthophosphate hydrogel: a potential drug delivery system. International Journal of Pharmaceutics, 371 1-2: 134-141. doi:10.1016/j.ijpharm.2009.01.018


Author Ta, Hang T.
Han, Han
Larson, Ian
Dass, Crispin R.
Dunstan, Dave E.
Title Chitosan-dibasic orthophosphate hydrogel: a potential drug delivery system
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
1873-3476
Publication date 2009-04-17
Sub-type Article (original research)
DOI 10.1016/j.ijpharm.2009.01.018
Open Access Status
Volume 371
Issue 1-2
Start page 134
End page 141
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 3003 Pharmaceutical Science
Abstract Injectable thermo-activated hydrogels have shown great potential in biomedical applications including use in therapeutic delivery vehicles. In addition to their biocompatibility, the feasibility of these delivery systems is significantly contributed by their ability to gel at physiological conditions and to release entrapped molecules in a sustained manner. In this study, parameters affecting the gelling behavior and the release characteristics of a neutral hydrogel system based on chitosan and an inorganic orthophosphate salt have been investigated. Monobasic and tribasic phosphate salts were not effective in inducing gelation of chitosan solution. However, in the presence of dibasic phosphate salt such as dipotassium hydrogen orthophosphate (DHO), the acidic chitosan solution was neutralized and gelling at temperature and time regulated by varying chitosan and salt concentrations in the formulation. The release rate of the entrapped macromolecules depended on chitosan concentration, DHO concentration, structural conformation and molecular weight of entrapped agents. The relationship between the morphology of the hydrogel and the release profiles are discussed. Chitosan/DHO (Chi/DHO) hydrogels were found to be cytocompatible as evaluated in an in vitro study using a human cell line. These results indicate the potential of Chi/DHO hydrogels as delivery systems for different therapeutic agents with controlled release kinetics. Crown Copyright
Keyword Chitosan
Cytocompatible
Delivery
Gelation
Hydrogel
Orthophosphate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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