The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma

Hacker, E., Boyce, Z., Kimlin, M.G., Wockner, L., Pollak, T., Vaartjes, S.A., Hayward, N.K. and Whiteman, D.C. (2013) The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma. Pigment Cell and Melanoma Research, 26 6: 835-844. doi:10.1111/pcmr.12157

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Hacker, E.
Boyce, Z.
Kimlin, M.G.
Wockner, L.
Pollak, T.
Vaartjes, S.A.
Hayward, N.K.
Whiteman, D.C.
Title The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
Journal name Pigment Cell and Melanoma Research   Check publisher's open access policy
ISSN 1755-1471
1755-148X
Publication date 2013
Sub-type Article (original research)
DOI 10.1111/pcmr.12157
Open Access Status
Volume 26
Issue 6
Start page 835
End page 844
Total pages 10
Place of publication Malden, MA, U.S.A.
Publisher Wiley-Blackwell Publishing, Inc.
Collection year 2014
Language eng
Subject 2708 Dermatology
2730 Oncology
1300 Biochemistry, Genetics and Molecular Biology
Abstract Summary: We conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar-simulated ultraviolet radiation (SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose (MED) SSUVR was twofold higher than baseline (unirradiated) skin. However, the change in epidermal melanocyte counts among people carrying germline MC1R variants (97% increase) was significantly less than those with wild-type MC1R (164% increase; P = 0.01). We also found that sunscreen applied to the skin before exposure to 2 MED SSUVR completely blocked the effects of DNA damage, p53 induction, and cellular proliferation in both melanocytes and keratinocytes.
Keyword MC1R
Melanocytes
Melanoma
Proliferation
Sun exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 03 Apr 2014, 13:58:48 EST by Matthew Lamb on behalf of School of Medicine