Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study

Kreijkamp-Kaspers S., Kok L., Bots M.L., Grobbee D.E. and Van Der Schouw Y.T. (2005) Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study. Atherosclerosis, 178 1: 95-100. doi:10.1016/j.atherosclerosis.2004.06.002


Author Kreijkamp-Kaspers S.
Kok L.
Bots M.L.
Grobbee D.E.
Van Der Schouw Y.T.
Title Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2004.06.002
Volume 178
Issue 1
Start page 95
End page 100
Total pages 6
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Objective: Isoflavone supplementation in high doses is associated with plasma lipid, glucose and insulin levels. Little is known about the effects of intake within the range of western diets on these endpoints. Design: We conducted a population-based cross-sectional study in 301 women aged 60-75 years. Methods: Dietary isoflavone and lignan intake was assessed with a food frequency questionnaire covering habitual diet during the year preceding enrolment. The outcome measures were total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, Lp(a), fasting glucose and insulin levels. Data were analysed using linear regression and logistic regression models. In the analyses we adjusted for a wide range of potential confounders. Results: High intake of isoflavones was associated with lower Lp(a) levels (tertile three versus tertile one: odds ratio 0.36, 95% CI 0.16; 0.80). No relation was found between blood levels and the other plasma lipids, glucose or insulin was found. Conclusion: The results of this study suggest that an effect of dietary phytoestrogen intake at low levels on plasma lipid levels is of limited magnitude. It is premature to advise postmenopausal women with low phytoestrogen intake to change their diet towards a phytoestrogen rich diet with the sole aim to prevent cardiovascular disease.
Keyword Diet
Isoflavones
Lignans
Menopause
Phytoestrogens
Plasma lipids
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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