Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study

Chaparro, A., Sanz, A., Quintero, A., Inostroza, C., Ramirez, V., Carrion, F., Figueroa, F., Serra, R. and Illanes, S. E. (2013) Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study. Journal of Periodontal Research, 48 3: 302-307. doi:10.1111/jre.12008

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Author Chaparro, A.
Sanz, A.
Quintero, A.
Inostroza, C.
Ramirez, V.
Carrion, F.
Figueroa, F.
Serra, R.
Illanes, S. E.
Title Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study
Journal name Journal of Periodontal Research   Check publisher's open access policy
ISSN 0022-3484
1600-0765
Publication date 2013
Sub-type Article (original research)
DOI 10.1111/jre.12008
Open Access Status
Volume 48
Issue 3
Start page 302
End page 307
Total pages 6
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Collection year 2014
Language eng
Formatted abstract
Aim(s): To explore the relationship between biomarkers of systemic inflammation in plasma and gingival crevicular fluid in early pregnancy and the subsequent development of pre-eclampsia in patients with periodontitis.

Materials and Methods: A case-control study was performed. From a cohort composed of 126 pregnant women, 43 normotensive healthy pregnant women were randomly selected, and 11 cases of preeclampsia were identified. Plasmatic and gingival crevicular fluid (GCF) samples were collected in early pregnancy (11-14 wk gestation). The levels of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were measured in the plasma and GCF samples, whereas the level of C-reactive protein (CRP) was measured in plasma samples. Biomarkers were determined by ELISA assays. The data were analysed using descriptive statistics, and the association between variables was estimated through logistic regression models.

Results: There was observed an association between pre-eclampsia and plasmatic levels of CRP (OR: 1.07; p = 0.003). Additionally, pre-eclampsia also was associated with IL-6 levels in GCF samples in early pregnancy (OR: 1.05; p = 0.039). A multiple logistic regression model suggests that increased levels of IL-6 in GCF (OR = 1.06; p = 0.02; CI 95% 1.007-1.117) in early pregnancy increase the risk of developing pre-eclampsia.

Conclusion(s): Pregnant women with periodontitis who later development pre-eclampsia, shows increased levels of IL-6 in GCF and CRP in plasma during early pregnancy. Periodontal disease could contribute to systemic inflammation in early pregnancy via a local increase of IL-6 and the systemic elevation of CRP. Therefore, both inflammatory markers could be involved in the relationship between periodontal disease and pre-eclampsia. 
Keyword C-reactive protein
Interleukin-6
Periodontal disease
Pre-eclampsia
Pregnancy
Systemic inflammation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Wed, 02 Apr 2014, 13:17:18 EST by Roheen Gill on behalf of UQ Centre for Clinical Research