Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia

Perez-Sepulveda, Alejandra, Espana-Perrot, Pedro P., Norwitz, Errol R. and Illanes, Sebastian E. (2013) Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia. Reproductive Sciences, 20 9: 1020-1029. doi:10.1177/1933719113477483

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Author Perez-Sepulveda, Alejandra
Espana-Perrot, Pedro P.
Norwitz, Errol R.
Illanes, Sebastian E.
Title Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia
Journal name Reproductive Sciences   Check publisher's open access policy
ISSN 1933-7191
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1177/1933719113477483
Open Access Status DOI
Volume 20
Issue 9
Start page 1020
End page 1029
Total pages 10
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2014
Language eng
Subject 2729 Obstetrics and Gynaecology
Abstract Preeclampsia (PE) remains a major cause of maternal/fetal morbidity-mortality worldwide. The first stage of PE is characterized by placental hypoxia due to a relative reduction in uteroplacental blood flow, resulting from restricted trophoblast invasion. However, hypoxia is also an essential element for the success of invasion. Under hypoxic conditions, 2-methoxyestradiol (2-ME) could induce the differentiation of cytotrophoblast cells into an invasive phenotype in culture. 2-Methoxyestradiol is generated by catechol-O-methyltransferase, an enzyme involved in the metabolic pathway of estrogens. During pregnancy, circulating 2-ME levels increase significantly when compared to the menstrual cycle. Interestingly, plasma levels of 2-ME are lower in women with PE than in controls, and these differences are apparent weeks or even months before the clinical manifestations of the disease. This article reviews the metabolic pathways involved in 2-ME synthesis and discusses the roles of these pathways in normal and abnormal pregnancies, with particular emphasis on PE.
Keyword Aromatase
Methionine homocysteine metabolism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Wed, 02 Apr 2014, 13:15:57 EST by Roheen Gill on behalf of UQ Centre for Clinical Research