Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus

Lowder, Bethan V., Guinane, Caitriona M., Ben Zakour, Nouri L., Weinert, Lucy A., Conway-Morris, Andrew, Cartwright, Robyn A., Simpson, A. John, Rambaut, Andrew, Nubel, Ulrich and Fitzgerald, J. Ross (2009) Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America, 106 46: 19545-19550. doi:10.1073/pnas.0909285106


Author Lowder, Bethan V.
Guinane, Caitriona M.
Ben Zakour, Nouri L.
Weinert, Lucy A.
Conway-Morris, Andrew
Cartwright, Robyn A.
Simpson, A. John
Rambaut, Andrew
Nubel, Ulrich
Fitzgerald, J. Ross
Title Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2009-11-17
Year available 2009
Sub-type Article (original research)
DOI 10.1073/pnas.0909285106
Open Access Status
Volume 106
Issue 46
Start page 19545
End page 19550
Total pages 6
Place of publication Washington, DC United States
Publisher National Academy of Sciences
Collection year 2010
Language eng
Subject 1000 General
Formatted abstract
The impact of globalization on the emergence and spread of pathogens is an important veterinary and public health issue. Staphylococcus aureus is a notorious human pathogen associated with serious nosocomial and community-acquired infections. In addition, S. aureus is a major cause of animal diseases including skeletal infections of poultry, which are a large economic burden on the global broiler chicken industry. Here, we provide evidence that the majority of S. aureus isolates from broiler chickens are the descendants of a single human-to-poultry host jump that occurred approximately 38 years ago (range, 30 to 63 years ago) by a subtype of the worldwide human ST5 clonal lineage unique to Poland. In contrast to human subtypes of the ST5 radiation, which demonstrate strong geographic clustering, the poultry ST5 clade was distributed in different continents, consistent with wide dissemination via the global poultry industry distribution network. The poultry ST5 clade has undergone genetic diversification from its human progenitor strain by acquisition of novel mobile genetic elements from an avian-specific accessory gene pool, and by the inactivation of several proteins important for human disease pathogenesis. These genetic events have resulted in enhanced resistance to killing by chicken heterophils, reflecting avian host-adaptive evolution. Taken together, we have determined the evolutionary history of a major new animal pathogen that has undergone rapid avian host adaptation and intercontinental dissemination. These data provide a new paradigm for the impact of human activities on the emergence of animal pathogens. 
Keyword Evolution
Globalization
Host adaptation
Pathogen
Phylogeography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 149 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 153 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Apr 2014, 22:27:22 EST by Nouri Ben Zakour on behalf of School of Chemistry & Molecular Biosciences