Oral mucosa: physiological and physicochemical aspects

Yakubov, Gleb E., Gibbins, Hannah, Proctor, Gordon B. and Carpenter, Guy H. (2014). Oral mucosa: physiological and physicochemical aspects. In Vitaliy V. Khutoryanskiy (Ed.), Mucoadhesive Materials and Drug Delivery Systems (pp. 3-37) Chichester, West Sussex, UK: John Wiley & Sons. doi:10.1002/9781118794203.ch01

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Yakubov, Gleb E.
Gibbins, Hannah
Proctor, Gordon B.
Carpenter, Guy H.
Title of chapter Oral mucosa: physiological and physicochemical aspects
Title of book Mucoadhesive Materials and Drug Delivery Systems
Place of Publication Chichester, West Sussex, UK
Publisher John Wiley & Sons
Publication Year 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/9781118794203.ch01
Open Access Status
ISBN 9781119941439
9781118794371
9781118794395
9781118794203
Editor Vitaliy V. Khutoryanskiy
Chapter number 1
Start page 3
End page 37
Total pages 35
Total chapters 14
Collection year 2015
Language eng
Formatted Abstract/Summary
The current review focuses on the structure and function of mucosa on soft oral tissues, since soft surfaces are key targets for oral transmucosal drug carriers.

Oral mucosa is a highly diverse, dynamic and responsive environment that despite high accessibility presents a number of challenges for oral drug delivery and food processing alike. This chapter focuses on the structure and physiological and physicochemical functions of mucosa on soft oral tissues, since soft surfaces are key targets for oral transmucosal drug carriers. There are six major classes of salivary proteins/glycoproteins: mucins (represented by MUC5B and MUC7 genetic types); acidic, basic and heavily glycosylated proline-rich proteins; salivary amylases; statherins; histatins; and cystatins. Salivary pellicle is critical factor in transport properties of topically delivered drugs and colloidal drug carriers. The chapter discusses the surface architecture, and mechanical, rheological and transport properties of salivary pellicle.
Keyword Drug delivery systems
Oral cavity tissues
Oral mucosa
Physicochemical properties
Physiological functions
Salivary glands
Salivary pellicle
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 27 Mar 2014, 22:01:35 EST by Gleb Yakubov on behalf of School of Chemical Engineering