Cardiovascular disease in the chronic kidney disease population - burden, pathophysiology and end-organ manifestations

Fahim, M. A. and Hawley, C. M. (2013). Cardiovascular disease in the chronic kidney disease population - burden, pathophysiology and end-organ manifestations. In Renal failure: prevention, causes and treatment (pp. 17-35) New York, United States: Nova Science Publishers.

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Name Description MIMEType Size Downloads
Author Fahim, M. A.
Hawley, C. M.
Title of chapter Cardiovascular disease in the chronic kidney disease population - burden, pathophysiology and end-organ manifestations
Title of book Renal failure: prevention, causes and treatment
Place of Publication New York, United States
Publisher Nova Science Publishers
Publication Year 2013
Sub-type Research book chapter (original research)
Open Access Status
Year available 2013
Series Renal and urologic disorders
ISBN 9781622578245
9781626187795
1626187797
Start page 17
End page 35
Total pages 19
Collection year 2014
Language eng
Subjects 2700 Medicine
Abstract/Summary Individuals with chronic kidney disease have a disproportionate risk of cardiovascular disease which accounts for the majority of the morbidity and mortality in this population. While traditional cardiovascular risk factors are overrepresented in the chronic kidney disease population, this alone is not sufficient to explain the excess risk observed. Chronic kidney disease is also associated with a number of novel pathophysiological mechanisms including salt and water retention, bone and mineral disorders, sympathetic overactivity and oxidative stress which combine to cause a number of pathological cardiovascular changes unique to chronic kidney disease. A greater understanding of these mechanisms is the first step to developing effective cardiac risk monitoring strategies and therapies. This chapter reviews the pathophysiology of cardiovascular disease in the chronic kidney disease population with a particular focus on those mechanisms unique to chronic kidney disease, their physiological consequences and end-organ effects.
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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Created: Tue, 25 Mar 2014, 01:34:35 EST by System User on behalf of Discipline of General Practice