Intensive language training enhances brain plasticity in chronic aphasia

Meinzer, Marcus, Elbert, Thomas, Wienbruch, Christian, Djundja, Daniela, Barthel, Gabriela and Rockstroh, Brigitte (2004) Intensive language training enhances brain plasticity in chronic aphasia. BMC Biology, 2 20: 1-9. doi:10.1186/1741-7007-2-20


Author Meinzer, Marcus
Elbert, Thomas
Wienbruch, Christian
Djundja, Daniela
Barthel, Gabriela
Rockstroh, Brigitte
Title Intensive language training enhances brain plasticity in chronic aphasia
Journal name BMC Biology   Check publisher's open access policy
ISSN 1741-7007
Publication date 2004-08-25
Sub-type Article (original research)
DOI 10.1186/1741-7007-2-20
Open Access Status DOI
Volume 2
Issue 20
Start page 1
End page 9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background
Focal clusters of slow wave activity in the delta frequency range (1–4 Hz), as measured by magnetencephalography (MEG), are usually located in the vicinity of structural damage in the brain. Such oscillations are usually considered pathological and indicative of areas incapable of normal functioning owing to deafferentation from relevant input sources. In the present study we investigated the change in Delta Dipole Density in 28 patients with chronic aphasia (>12 months post onset) following cerebrovascular stroke of the left hemisphere before and after intensive speech and language therapy (3 hours/day over 2 weeks).

Results
Neuropsychologically assessed language functions improved significantly after training. Perilesional delta activity decreased after therapy in 16 of the 28 patients, while an increase was evident in 12 patients. The magnitude of change of delta activity in these areas correlated with the amount of change in language functions as measured by standardized language tests.

Conclusions
These results emphasize the significance of perilesional areas in the rehabilitation of aphasia even years after the stroke, and might reflect reorganisation of the language network that provides the basis for improved language functions after intensive training.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Mon, 24 Mar 2014, 11:13:43 EST by Marcus Meinzer on behalf of UQ Centre for Clinical Research