Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena

Cervin, Anders, Greiff, Lennart, Lindberg, Sven and Andersson, Morgan (2002) Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena. ORL, 64 1: 26-31. doi:10.1159/000049264

Author Cervin, Anders
Greiff, Lennart
Lindberg, Sven
Andersson, Morgan
Title Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena
Journal name ORL   Check publisher's open access policy
ISSN 0301-1569
Publication date 2002-01
Sub-type Article (original research)
DOI 10.1159/000049264
Open Access Status Not yet assessed
Volume 64
Issue 1
Start page 26
End page 31
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Formatted abstract
Background: Increased levels of nitric oxide (NO) and the exudations of plasma proteins to the airway lumen have both been considered characteristics of airway inflammation. The aim of the present study was to investigate a possible relationship between nasal NO concentrations and acutely induced exudative inflammation of the nasal mucosa.

Methods: Twelve healthy non-allergic subjects participated. Nasal challenges with saline, histamine 40 μg/ml (H1), histamine 400 μg/ml (H2), oxymethazoline, 0.25 mg/ml (OXY), and a combination of oxymethazoline 0.25 mg/ml and histamine 800 μg/ml (OXYH), were performed on separate occasions. Exhaled NO was measured after each challenge, and α2-macroglobulin (as a marker of plasma exudation) was measured in nasal lavage fluids after the H1 and H2 challenges.

Results: The mean baseline NO in all measurements was 164 ± 10.3 ppb. Saline and H1 challenge did not change NO and α2-macroglobulin levels. H2 challenge showed a tendency to reduce NO levels, and the most pronounced decrease was seen after 10 min (-36.3 ± 16.3%, p = 0.07). This reduction was sustained throughout the registration period. Simultanousley with the decrease in NO, α2-macroglobulin levels were increased significantly. OXY challenge alone reduced NO significantly throughout the whole registration period. Maximum decrease was seen at 40 min (-21.3 ± 3.4%, p = 0.03). The OXYH challenge also reduced NO, with a maximal reduction recorded at 10 min (-29.4 ± 6.4%, p = 0.03). The reduction of NO was sustained throughout the registration period (p < 0.01).

Conclusion: Histamine 400 μg/ml induced a prompt plasma exudation response whereas a decrease in nasal NO was registered, suggesting that these two events are not necessarily linked. Furthermore it was shown that the vasoconstrictor oxymethazoline reduced nasal NO, which could be related to reduced mucosal blood flow, whereas the reduction of nasal NO after histamine challenge remains to be elucidated.
Keyword α2-Macroglobulin
Nitric oxide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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