Very high-resolution three-dimensional functional MRI of the human visual cortex with elimination of large venous vessels

Barth, M. and Norris, D. G. (2007) Very high-resolution three-dimensional functional MRI of the human visual cortex with elimination of large venous vessels. NMR in Biomedicine, 20 5: 477-484. doi:10.1002/nbm.1158


Author Barth, M.
Norris, D. G.
Title Very high-resolution three-dimensional functional MRI of the human visual cortex with elimination of large venous vessels
Journal name NMR in Biomedicine   Check publisher's open access policy
ISSN 0952-3480
1099-1492
Publication date 2007-08
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1002/nbm.1158
Open Access Status Not yet assessed
Volume 20
Issue 5
Start page 477
End page 484
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract We propose a very high-resolution, three-dimensional (3D) gradient-echo technique with a twofold parallel imaging acceleration using a specialized occipital receiver coil at 3 T to perform functional MRI (fMRI) of the visual cortex. This configuration makes it possible to acquire 3D fMRI data within a timescale compatible with a block design. Without further processing, the functional maps at an isotropic 3D resolution of 0.42 μL (0.75mm voxel size) and near-isotropic resolution of 1.2 μl (1 mm voxel size) show very robust activation in visual areas, but with clear contamination from larger veins. As this technique allows direct identification of veins in the functional scan, it permits removal of their effect from the activation maps. In our study, elimination of veins qualitatively improves the spatial specificity of activation maps, while reducing the activated volume by about 25%. The proposed technique provides functional information at the resolution of anatomical scans, is localized to gray matter, and facilitates functional to anatomical co-registration because of minimal distortions.
Keyword Brain mapping
Functional activation
Neuroimaging
Parallel imaging
Venography
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Centre for Advanced Imaging Publications
 
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