Nonnvasive assessment of vascular architecture and function during modulated blood oxygenation using susceptibility weighted magnetic resonance imaging

Rauscher, Alexander, Sedlacik, Jan, Barth, Markus, Haacke, E. Mark and Reichenbach, Juergen R. (2005) Nonnvasive assessment of vascular architecture and function during modulated blood oxygenation using susceptibility weighted magnetic resonance imaging. Magnetic Resonance in Medicine, 54 1: 87-95. doi:10.1002/mrm.20520


Author Rauscher, Alexander
Sedlacik, Jan
Barth, Markus
Haacke, E. Mark
Reichenbach, Juergen R.
Title Nonnvasive assessment of vascular architecture and function during modulated blood oxygenation using susceptibility weighted magnetic resonance imaging
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1002/mrm.20520
Open Access Status Not yet assessed
Volume 54
Issue 1
Start page 87
End page 95
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Susceptibility weighted imaging (SWI) is a BOLD-sensitive method for visualizing anatomical features such as small cerebral veins in high detail. The purpose of this study was to evaluate high-resolution SWI in combination with a modulation of blood oxygenation by breathing of air, carbogen, and oxygen and to directly visualize the effects of changing blood oxygenation on the magnetic field inside and around venous blood vessels. Signal changes associated with the response to carbogen and oxygen breathing were evaluated in different anatomic regions in healthy volunteers and in two patients with brain tumors. In the magnitude images inhalation of carbogen led to significant signal intensity changes ranging from +4.4 ± 1.9% to +9.5 ± 1.4% in gray matter and no significant changes In thalamus, putamen, and white matter. During oxygen breathing mean signal changes were smaller than during carbogen breathing. The method is capable of producing high-resolution functional maps of BOLD response to carbogen and oxygen breathing as well as high-resolution images of venous vasculature. Its sensitivity to changes in blood oxygenation was demonstrated by in vivo visualization of the BOLD effect via phase imaging.
Keyword BOLD
Brain
Carbogen
MRI
Susceptibility weighted imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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