Layer-specific BOLD activation in human V1

Koopmans, Peter J., Barth, Markus and Norris, David G. (2010) Layer-specific BOLD activation in human V1. Human Brain Mapping, 31 9: 1297-1304. doi:10.1002/hbm.20936

Author Koopmans, Peter J.
Barth, Markus
Norris, David G.
Title Layer-specific BOLD activation in human V1
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
Publication date 2010
Sub-type Article (original research)
DOI 10.1002/hbm.20936
Open Access Status
Volume 31
Issue 9
Start page 1297
End page 1304
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract The neocortex is known to have a distinct laminar structure which has previously been probed in animals using high-resolution fMRI. Detection of layer-specific activation in humans has however to date proven elusive. In this study we demonstrate for the first time such layer-specific activation, specifically at a depth corresponding to layer IV of human primary visual cortex (V1). We used a gradient-echo (GE) sequence at 3T with an isotropic resolution of 0.75 mm, in which a stria at the depth of layer IV was visible in the averaged time series, and could be used as an anatomical landmark. Upon visual stimulation (7.5 Hz flickering checkerboard) the signal increase of 3% in layer IV was significantly higher than in the neighboring laminae. The width of this activation peak was 0.8-1 mm. Based on this result and known laminar organization of the intracortical vasculature we conclude that in the direction perpendicular to the cortical surface the intrinsic spatial resolution of the GE-BOLD fMRI signal is in the submillimetre range. Human laminar fMRI is a significant development which may improve our understanding of intracortical activation patterns and of the way in which different cortical regions interact.
Keyword 3 Tesla
BOLD spatial resolution
Cortical layers
Functional MRI
Striate cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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