Memory stabilization with targeted reactivation during human slow-wave sleep

van Dongen, Eelco V., Takashima, Atsuko, Barth, Markus, Zapp, Jascha, Schad, Lothar R., Paller, Ken A. and Fernandez, Guillén (2012) Memory stabilization with targeted reactivation during human slow-wave sleep. Proceedings of the National Academy of Sciences of the United States of America, 109 26: 10575-10580. doi:10.1073/pnas.1201072109


Author van Dongen, Eelco V.
Takashima, Atsuko
Barth, Markus
Zapp, Jascha
Schad, Lothar R.
Paller, Ken A.
Fernandez, Guillén
Title Memory stabilization with targeted reactivation during human slow-wave sleep
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2012-06-26
Sub-type Article (original research)
DOI 10.1073/pnas.1201072109
Open Access Status
Volume 109
Issue 26
Start page 10575
End page 10580
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Language eng
Abstract It is believed that neural representations of recent experiences become reactivated during sleep, and that this process serves to stabilize associated memories in long-term memory. Here, we initiated this reactivation process for specific memories during slow-wave sleep. Participants studied 50 object-location associations with object-related sounds presented concurrently. For half of the associations, the related sounds were re-presented during subsequent slow-wave sleep while participants underwent functional MRI. Compared with control sounds, related sounds were associated with increased activation of right parahippocampal cortex. Postsleep memory accuracy was positively correlated with sound-related activation during sleep in various brain regions, including the thalamus, bilateral medial temporal lobe, and cerebellum. In addition, postsleep memory accuracy was also positively correlated with pre- to postsleep changes in parahippocampal-medial prefrontal connectivity during retrieval of reactivated associations. Our results suggest that the brain is differentially activated by studied and unstudied sounds during deep sleep and that the thalamus and medial temporal lobe are involved in establishing the mnemonic consequences of externally triggered reactivation of associative memories.
Keyword Consolidation
EEG-functional MRI
Neuroimaging
Replay
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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