NOD-like receptors in the human upper airways: a potential role in nasal polyposis

Mansson, A., Bogefors, J., Cervin, A., Uddman, R. and Cardell, L. O. (2011) NOD-like receptors in the human upper airways: a potential role in nasal polyposis. Allergy: European Journal of Allergy and Clinical Immunology, 66 5: 621-628. doi:10.1111/j.1398-9995.2010.02527.x


Author Mansson, A.
Bogefors, J.
Cervin, A.
Uddman, R.
Cardell, L. O.
Title NOD-like receptors in the human upper airways: a potential role in nasal polyposis
Journal name Allergy: European Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0105-4538
1398-9995
Publication date 2011
Sub-type Article (original research)
DOI 10.1111/j.1398-9995.2010.02527.x
Open Access Status
Volume 66
Issue 5
Start page 621
End page 628
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Background: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are newly discovered cytosolic receptors belonging to the pattern-recognition receptor family. They detect various pathogen-associated molecular patterns, triggering an immune response. The knowledge about these receptors, and their role in health and disease, is limited. The aim of the present study was to characterize the expression of NOD1, NOD2, and NALP3 in the human upper airways.

Methods: Surgical samples were obtained from patients with tonsillar disease (n = 151), hypertrophic adenoids (n = 9), and nasal polyposis (n = 24). Nasal biopsies were obtained from healthy volunteers (n = 10). The expression of NOD1, NOD2, and NALP3 was analyzed using real-time PCR and immunohistochemistry.

Results: Expression of NOD1, NOD2, and NALP3 mRNA and protein were seen in all tissue specimens. The NLR mRNA was found to be higher in nasal polyps than in normal nasal mucosa, and local steroid treatment reduced the NLR expression in polyps. In contrast, tonsillar infection with Streptococcus pyogenes or Haemophilus influenzae did not affect the NLR expression.

Conclusions: The present study demonstrates the presence of NLRs in several upper airway tissues and highlights a potential role of NLRs in chronic rhinosinusitis with polyps.
Keyword Epithelium
Innate immunity
Nasal polyps
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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