Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroids

Cervin A., Hansson C., Greiff L. and Andersson M. (2003) Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroids. ORL, 65 2: 103-105. doi:10.1159/000070774


Author Cervin A.
Hansson C.
Greiff L.
Andersson M.
Title Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroids
Journal name ORL   Check publisher's open access policy
ISSN 0301-1569
Publication date 2003
Sub-type Article (original research)
DOI 10.1159/000070774
Volume 65
Issue 2
Start page 103
End page 105
Total pages 3
Language eng
Subject 2733 Otorhinolaryngology
Abstract Background: Mucosal ulcers and perforations of the nasal septum are very rare and may have several underlying causes. Contact allergy to steroids has been suggested as a possible aetiological factor in patients who develop perforations during topical steroid use. Methods: We have identified 13 subjects with perforations of their nasal septum and concomitant topical nasal steroid use. In order to evaluate whether these patients had developed contact allergy to steroids they underwent patch testing with an extended steroid series. Results: None of the subjects displayed any positive reaction to the steroids. Conclusion: Sensitivity to glucocorticoids is a well-described phenomenon and may in selected subjects also be associated with local side effects to nasal sprays. However, contact allergy to steroids does not seem to be a general explanation for septal perforations in patients using nasal steroids. Copyright
Keyword Contact allergy
Nasal septum
Topical glucocorticosteroid
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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