A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Hinds, David A., McMahon, George, Kiefer, Amy K., Do, Chuong B., Eriksson, Nicholas, Evans, David M., St Pourcain, Beate, Ring, Susan M., Mountain, Joanna L., Francke, Uta, Davey-Smith, George, Timpson, Nicholas J. and Tung, Joyce Y. (2013) A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nature Genetics, 45 8: 907-911. doi:10.1038/ng.2686

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Author Hinds, David A.
McMahon, George
Kiefer, Amy K.
Do, Chuong B.
Eriksson, Nicholas
Evans, David M.
St Pourcain, Beate
Ring, Susan M.
Mountain, Joanna L.
Francke, Uta
Davey-Smith, George
Timpson, Nicholas J.
Tung, Joyce Y.
Title A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2686
Open Access Status File (Author Post-print)
Volume 45
Issue 8
Start page 907
End page 911
Total pages 5
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2014
Language eng
Subject 1311 Genetics
Abstract Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P < 5 × 10-8, including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P = 5.3 × 10 -21); 6p21.33 near HLA-C and MICA (rs9266772, P = 3.2 × 10 -12); 5p13.1 near PTGER4 (rs7720838, P = 8.2 × 10 -11); 2q33.1 in PLCL1 (rs10497813, P = 6.1 × 10-10), 3q28 in LPP (rs9860547, P = 1.2 × 10-9); 20q13.2 in NFATC2 (rs6021270, P = 6.9 × 10-9), 4q27 in ADAD1 (rs17388568, P = 3.9 × 10-8); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P = 4.8 × 10-8). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P = 1.7 × 10-12), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.
Keyword Allergic disease
Genome wide association
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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